The benefit of aspirin is far greater than its harm
Professor Dr. E. Murat Tuzcu, side effects of aspirin, as well as the "camel ear" remains, he says.
The benefits of aspirin are always on the agenda. However, side effects are also mentioned. Professor Dr. E. Murat Tuzcu says in his article in Milliyet newspaper (26.01.09) that besides the benefits of aspirin, the side effects are like ”ears in a camel”. Tuzcu's article reads:
Ilaç Drugs with aspirin-like effects were known 3,000 years ago. Hippocrates says that a drug made from willow bark - a substance similar to aspirin today - is good for pain. Modern aspirin, first introduced in 1898, was used as a painkiller for many years. In the 1940s, a doctor in California observed that his patients, who had given aspirin for pain, did not have a heart attack. It took 25 years to understand how this positive effect was achieved.
platelets
A heart attack is caused by a clot formed inside the vein. The first building blocks in clot formation are blood cells called platelets. There are three different cells in our blood; red blood cells that carry oxygen and give blood a red color; white blood cells that protect us against germs; platelet
Because red blood cells are the heaviest cells, they are close to the center of the blood flowing; white blood cells outside; the lightest platelets circulate near the vessel wall.
If there is no condition that requires a clot in our body, platelets circulate in the blood calmly, quietly. When a place is cut, the platelets that move close to the wall immediately adhere to the torn wall and begin a change. Normally, platelets such as coins, round and flat, are smooth-surface, slippery cells. When stimulated and active, they change their shape and form recesses and protrusions on their surfaces and become sticky. This change can be compared to the recruitment of reserves in the event of mobilization. Like the protection of the borders of the country with their special clothes, equipment and weapons, and their appearance very different from their civilian status, platelets try to stop the bleeding and stop the bleeding.
Inviting platelets to enlist
Many factors stimulate and activate platelets. Some of these originate from the vessel wall, some from the blood, and some are substances secreted by platelets. We can simulate these warnings by sending letters to the reserves, by telegram, as well as making calls through radio and television channels.
The platelets, which reach the bleeding site and adhere to the wall, call on their friends to become active through the messenger substances they secrete into the blood and start to stick to each other. This creates a plug. If the incision is small, it's enough to stop the bleeding. If it is large, other substances are called for help and the clot is grown and strengthened.
How does aspirin work?
Aspirin stops the production of substances released by the platelets at the scene into the blood, activating other platelets and adhering to the wound site. Thus, a significant blow to the clot formation is reduced. However, aspirin acts only in one of several ways by which platelets become active and adhere to one another. The process, which continues in other ways, is not as effective as it used to be, but continues its work. Therefore, if someone who takes aspirin cuts his face while shaving, it will take longer than expected to stop the bleeding.
We don't necessarily have to cut off a place for platelets to start clotting. If the thin slippery layer that lays the inside of our veins, normally teflon, where nothing sticks, is scratched and damaged, they go there immediately and stick. Thus, the clot that begins, gradually grows, clogging the vein, causing a heart attack. Aspirin, to a certain extent, has a preventive effect on the occurrence of a heart attack as it stops this from the beginning.
Aspirin research
There is strong evidence that aspirin saves lives in high-risk patients. In an article published in the scientific journal of the British Medical Association (BMJ) in 1994, the data of 100 thousand patients examined in 175 studies were evaluated. It has been shown that those who have had heart attacks and strokes, patients with leg and brain vessels, and aspirin take the risk of recurrence. However, it has been shown to be useful in people with diabetes or high blood pressure, although there is no known heart disease. In this group, they were found to live healthier and longer if they were taking aspirin, albeit in the elderly.
A new study found that aspirin did not reduce the risk of heart attack but decreased the risk of stroke in women under 65 years of age. It is understood that women at high risk will benefit from aspirin even if they are not elderly.
Side effects of aspirin
Here's to the side effects of aspirin. They were also taken into account in this research. The most important side effect of aspirin is that it can cause bleeding. The most terrible bleeding, brain haemorrhage. Fortunately, this is only seen in one of the 10,000 aspirin sites. Stomach bleeding is more frequent. Aspirin is not seen between 1 and 2 per thousand; If you take aspirin, this risk increases to around 3 per thousand. Let's make an account; If we give aspirin to 1000 people who have had a heart attack, we prevent 40 new heart attacks that will occur in a month, and if we continue, we will protect 40 patients from new heart attacks in the next 2 years. Of these 1000 people, 3 or 4 suffer from bleeding in the stomach within a year. To take or not to get useful? Isn't the answer clear?
Should people who do not have cardiovascular disease should also take it? It is more difficult to answer the question m Should I take aspirin? In for those who have no cardiovascular disease and who have a high risk of being ill. To be able to respond correctly, the patient's risk of heart attack or stroke should be compared with the risk of bleeding.
4 studies in the United States and the United Kingdom, a known cardiovascular disease, some 50 thousand people, some aspirin-like aspirin, but similar to other hollow pill (placebo) was given. Aspirin patients had less heart attacks. It is better to dwell on this point. Aspirin, given to reduce a person's risk of having a heart attack from 3 percent to 2 percent within a year, is still very useful, although half the risk of bleeding increases. On the other hand, the risk of heart attack is half the risk of bleeding, even if we reduce it to 0.3 percent. It's best not to give aspirin to such a patient.
What should be the dose of aspirin?
We know that 75 mg aspirin is enough to prevent platelets from sticking together. The result of studies conducted on 10 thousands people is that there is no need for high doses. Nevertheless, I strongly advise you to decide with your doctor whether to take aspirin or not.
34AXX
Aspirin for Pain Relief and Headaches, 100 Tablets
